Research & Clinical Trials

Expanding Access to Advanced Cancer Care

At Hematology Oncology Associates of Fredericksburg, we are committed to providing our patients with access to the latest advancements in cancer and hematologic care. Through participation in carefully selected clinical trials, eligible patients may have the opportunity to receive innovative therapies that are not yet widely available. These research opportunities contribute to the advancement of medicine while offering additional treatment options for qualifying patients.

Our physicians and research team remain at the forefront of emerging therapies and are dedicated to helping patients understand whether participation in a clinical trial may be appropriate as part of their individualized treatment plan.

Infusion chair against window hematology oncology associates of fredericksburg the pines location

What Are Clinical Trials?

Clinical trials are carefully designed research studies that evaluate new medications, medical devices and treatment approaches to determine their safety and effectiveness. They are an essential part of the process that advances medical care and helps establish new standards of treatment.

Clinical trials may investigate whether a new therapy is more effective than existing treatments, offers fewer side effects or improves quality of life for patients. Every clinical trial conducted at HOAF is selected by our physicians and research staff based on its scientific merit and its potential to address the needs of our patients and the broader community.

Clinical research may focus on:

  • Improving methods for early detection of disease
  • Developing strategies to prevent illness in high-risk populations
  • Identifying new applications for established therapies
  • Evaluating novel medications and treatment combinations

Who May Be Eligible for a Clinical Trial?

At Hematology Oncology Associates of Fredericksburg, we offer clinical trials for a variety of cancer diagnoses, including studies targeting specific genetic or molecular characteristics identified through diagnostic testing. These precision medicine trials may provide treatment options tailored to an individual’s disease. We also participate in supportive care studies designed to improve symptom management and quality of life during treatment.

Each clinical trial has specific eligibility criteria based on factors such as diagnosis, stage of disease, prior treatments and overall health. Our experienced research nurse coordinators work closely with patients and their physicians to determine whether a particular study is an appropriate option.

If you are interested in learning more about clinical trial opportunities at HOAF, please contact our Research Department at HOAFresearch@aoncology.com. Our team will be happy to discuss studies that may be available for your condition.

The Phases Of Clinical Trials

Before a new medication or medical device receives approval from the U.S. Food and Drug Administration (FDA), it undergoes a rigorous evaluation through multiple phases of clinical research. Each phase is designed to answer specific questions regarding safety, effectiveness and long-term outcomes.

The first phase evaluates the safety of an investigational treatment, identifies appropriate dosage levels and monitors for potential side effects. These studies typically involve a small number of participants.

Once an acceptable safety profile has been established, Phase II studies evaluate how well the treatment works for patients with a specific disease while continuing to monitor its safety. These trials generally include a larger group of participants than Phase I.

Phase III trials compare the investigational treatment with the current standard of care to determine whether it provides improved outcomes. These large, multicenter studies often involve hundreds or thousands of participants and provide the evidence needed for FDA review and potential approval.

After FDA approval, Phase IV studies continue to monitor the treatment in broader patient populations. Researchers collect additional information regarding long-term safety, effectiveness and optimal use in routine clinical practice.

Protecting Patient Safety

Patient safety is the highest priority in every clinical trial conducted at HOAF. Clinical research is governed by strict ethical, scientific and regulatory standards designed to protect the rights, safety and well-being of every participant. Throughout the process, our research team carefully monitors each patient’s care and remains available to answer questions and provide ongoing support.

  • Informed Consent: Before enrolling in a clinical trial, you will participate in an informed consent discussion with a member of our research team. This conversation is intended to ensure you fully understand the purpose of the study, what participation involves, the expected duration, any required tests or procedures, potential risks and benefits and available alternatives to participation.

    You will have the opportunity to ask questions and take the time you need to make an informed decision. If you choose to participate, you will be asked to sign an informed consent document. Participation is always voluntary, and you may withdraw from a clinical trial at any time without affecting your access to medical care.

  • IRB Review: Before a clinical trial can begin, it must be reviewed and approved by an Institutional Review Board (IRB)—an independent committee composed of physicians, healthcare professionals, scientists and community representatives. The IRB evaluates each study to help ensure it is ethically conducted, that potential risks are minimized and reasonable in relation to anticipated benefits, and that the rights and welfare of participants are protected.

    The IRB continues to oversee approved studies throughout their duration to ensure ongoing compliance with established safety and ethical standards. If you have questions about the oversight of a specific clinical trial, our research coordinators will be happy to provide additional information.

Global Partnerships, Proven Experience

Over the years, HOAF has collaborated with top industry sponsors including:

  • AstraZeneca
  • Bristol Myers Squibb
  • Eli Lilly
  • GSK
  • Merck
  • Novartis
  • Roche
  • Pfizer

This experience allows us to offer patients access to trials across a wide range of disease states, including: genitourinary (GU), colorectal, esophageal, lung, breast, lymphoma, melanoma, myeloma, as well as biomarker-specific therapies and supportive care studies.

Our Achievements in Clinical Research

HOAF’s Clinical Trials Department is recognized for its excellence and rapid execution, with accomplishments such as:

  • Being the first U.S. site to open a trial
  • Enrolling the first patient in a study
  • Treating the first patient dosed
  • Ranking as a top-accruing site for multicenter studies
  • Maintaining high patient retention
  • Completing rapid study start-up timelines

Our track record demonstrates our commitment to efficient, high-quality research while providing patients with safe and personalized care throughout the study process.

Dr. Christopher Vaughn Discusses Expanding Access to Cancer Clinical Trials

Hematology Oncology Associates of Fredericksburg is proud to highlight Dr. Christopher Vaughn‘s participation in a recent Onco’Zine interview exploring the importance of bringing advanced cancer clinical trials closer to home. The discussion examines how precision oncology, molecular testing and collaborations with organizations such as Caris Life Sciences are helping expand access to innovative treatment opportunities within community oncology practices. Dr. Vaughn shares insights into HOAF’s efforts to connect patients with appropriate clinical trials while reducing the need for long-distance travel. His participation reflects HOAF’s ongoing commitment to advancing cancer care and providing patients in Fredericksburg and surrounding Virginia communities with personalized treatment options close to home.

Current Clinical Trials

We currently have a variety of open trials for patients in need of innovative cancer therapies. Our team is here to guide you through eligibility, enrollment, and treatment, ensuring you have the support and information you need every step of the way.

Contact us today to learn more about available clinical trials and how participation may benefit your care, or explore our current trials below.

HOAF Means Hope

Where Healing Begins, Strength Prevails

At HOAF, we are dedicated to providing exceptional care for cancer and blood disorders to the Fredericksburg, Stafford, and surrounding communities. Our practice integrates advanced treatments with a personalized approach, delivering the highest quality care. As an independent practice, we focus on individualized attention, ensuring each patient receives compassionate, comprehensive care tailored to their unique needs. Our cutting-edge facility, equipped with an on-site pharmacy, offers convenience and a seamless treatment experience.

Blue pathway
Patient holding hands with loved one during infusion
Patient holding hands with loved one during infusion